Do you have any physical limitations that would prevent you from wearing and performing in the costume effectively? Now is the time to figure out how to effectively get around the problem.
Do you wear glasses? You may want to try modifying the head to allow you to wear them either inside or out, or use contacts.
Do you have a leg/ambulatory/moving problem, requiring the use of a cane, wheelchair, or related to get around? These aids can still be used, though you may want to try using them differently or go with something else. Wheelchair users can easily do as well as those who walk, though they may have to modify the handpaws so they can move the chair around easily or have someone move them around.
You may opt to go for just a partial suit. One wheelchair user didn't even go for a full bodysuit. He just wore short sleeves and shorts, with the fur covering what the sleeves and shorts didn't. He had the arm pieces that went up to his shoulders, leg pieces that went under his shorts, tail that went in his lap, and a regular head.
Do you have missing limbs, like an arm or leg? This may require a little creativity in this area.
Any others not mentioned here?
Here's one example of someone who didn't try to hide their back brace, but made it look like a fashion statement - http://users.netmatters.co.uk/ju90/cylife.htm